泊利噻嗪
TL;DR: 泊利噻嗪 (CAS 346-18-9) is a chemical compound with molecular formula C11H13ClF3N3O4S3 and molecular weight 438.97 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
泊利噻嗪
6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
Also Known As: polythiazide, Renese, Drenusil, Nephril, Politiazida
| Molecular Formula | C11H13ClF3N3O4S3 |
|---|---|
| Molecular Weight | 438.97 g/mol |
| LogP | 2.6 |
| Topological Polar Surface Area | 152.0 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 11 |
| Rotatable Bonds | 4 |
| Exact Mass | 438.9709 |
| Heavy Atoms | 25 |
| Complexity | 692.0 |
| Melting Point | 202.5 °C |
| Solubility | less than 1 mg/mL at 68 °F (NTP, 1992) |
Chemical Identifiers
| CAS Number | 346-18-9 |
|---|---|
| SMILES | CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CSCC(F)(F)F |
| InChIKey | CYLWJCABXYDINA-UHFFFAOYSA-N |
Patent-Derived Application Labels
Derived from 13 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
泊利噻嗪 (CAS 346-18-9), with molecular formula C11H13ClF3N3O4S3 and molecular weight 438.97 g/mol. IUPAC: 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide.
Chemical Property Profile of 泊利噻嗪
Property Insights of 泊利噻嗪
The XLogP value of 2.6 suggests moderate lipophilicity, balancing water solubility and membrane permeability for 泊利噻嗪. The TPSA of 152.0 Ų indicates high polarity, suggesting 泊利噻嗪 may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, 泊利噻嗪 has 2 hydrogen bond donor(s) and 11 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 泊利噻嗪?
The CAS number of 泊利噻嗪 is 346-18-9.
What is the molecular formula of 泊利噻嗪?
The molecular formula of 泊利噻嗪 is C11H13ClF3N3O4S3.
What is the molecular weight of 泊利噻嗪?
The molecular weight of 泊利噻嗪 is 438.97 g/mol.
Where can I buy 泊利噻嗪?
You can request a quote for 泊利噻嗪 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 泊利噻嗪?
Yes, KEHONG BIO provides custom synthesis services for 泊利噻嗪 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.