DAPT
TL;DR: DAPT (CAS 208255-80-5) is a chemical compound with molecular formula C23H26F2N2O4 and molecular weight 432.19 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
DAPT
tert-butyl 2-[2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoylamino]-2-phenylacetate
Also Known As: dapt, GSI-IX, DAPT (GSI-IX), A-Secretase Inhibitor Dapt, gamma-Secretase Inhibitor IX
| Molecular Formula | C23H26F2N2O4 |
|---|---|
| Molecular Weight | 432.19 g/mol |
| LogP | 3.7 |
| Topological Polar Surface Area | 84.5 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 9 |
| Exact Mass | 432.18607 |
| Heavy Atoms | 31 |
| Complexity | 622.0 |
Chemical Identifiers
| CAS Number | 208255-80-5 |
|---|---|
| SMILES | CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F |
| InChIKey | DWJXYEABWRJFSP-UHFFFAOYSA-N |
Product Overview
DAPT (CAS 208255-80-5), with molecular formula C23H26F2N2O4 and molecular weight 432.19 g/mol. IUPAC: tert-butyl 2-[2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoylamino]-2-phenylacetate.
Chemical Property Profile of DAPT
Property Insights of DAPT
The XLogP value of 3.7 indicates that dapt is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 84.5 Ų falls within the moderate polarity range, balancing permeability and solubility for DAPT. Following Lipinski's Rule of Five, dapt has 2 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of dapt?
The CAS number of dapt is 208255-80-5.
What is the molecular formula of dapt?
The molecular formula of dapt is C23H26F2N2O4.
What is the molecular weight of dapt?
The molecular weight of dapt is 432.19 g/mol.
Where can I buy dapt?
You can request a quote for dapt directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for dapt?
Yes, KEHONG BIO provides custom synthesis services for dapt and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.