Lopac-A-1784
TL;DR: Lopac-A-1784 (CAS 143873-72-7) is a chemical compound with molecular formula C19H20N8O5 and molecular weight 440.16 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Also Known As: aminopterin, Lopac-A-1784, (2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid, D-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
| Molecular Formula | C19H20N8O5 |
|---|---|
| Molecular Weight | 440.16 g/mol |
| LogP | 0.2441 |
| Topological Polar Surface Area | 219.33 Ų |
| Hydrogen Bond Donors | 6 |
| Hydrogen Bond Acceptors | 10 |
| Rotatable Bonds | 9 |
| Exact Mass | 440.15567 |
| Heavy Atoms | 32 |
| Complexity | 1168.3418 |
Chemical Identifiers
| CAS Number | 143873-72-7 |
|---|---|
| SMILES | C1=CC(=CC=C1C(=O)N[C@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N |
Product Overview
Lopac-A-1784 (CAS 143873-72-7), with molecular formula C19H20N8O5 and molecular weight 440.16 g/mol. IUPAC: (2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid.
Chemical Property Profile of Lopac-A-1784
Property Insights of Lopac-A-1784
The XLogP value of 0.2441 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Lopac-A-1784. The TPSA of 219.33 Ų indicates high polarity, suggesting Lopac-A-1784 may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, Lopac-A-1784 has 6 hydrogen bond donor(s) and 10 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Lopac-A-1784?
The CAS number of Lopac-A-1784 is 143873-72-7.
What is the molecular formula of Lopac-A-1784?
The molecular formula of Lopac-A-1784 is C19H20N8O5.
What is the molecular weight of Lopac-A-1784?
The molecular weight of Lopac-A-1784 is 440.16 g/mol.
Where can I buy Lopac-A-1784?
You can request a quote for Lopac-A-1784 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Lopac-A-1784?
Yes, KEHONG BIO provides custom synthesis services for Lopac-A-1784 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.