范得他尼
TL;DR: 范得他尼 (CAS 1174683-49-8) is a chemical compound with molecular formula C22H24BrFN4O2 and molecular weight 474.11 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
范得他尼
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Also Known As: Vandetanib, Zactima, Caprelsa, Vandetanib [INN], vandetanibum
| Molecular Formula | C22H24BrFN4O2 |
|---|---|
| Molecular Weight | 474.11 g/mol |
| LogP | 5.0042 |
| Topological Polar Surface Area | 59.51 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 6 |
| Exact Mass | 474.10666 |
| Heavy Atoms | 30 |
| Complexity | 1041.0664 |
Chemical Identifiers
| CAS Number | 1174683-49-8 |
|---|---|
| SMILES | CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC |
Product Overview
范得他尼 (CAS 1174683-49-8), with molecular formula C22H24BrFN4O2 and molecular weight 474.11 g/mol. IUPAC: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine.
Chemical Property Profile of 范得他尼
Property Insights of 范得他尼
The XLogP value of 5.0042 indicates that 范得他尼 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 59.51 Ų, 范得他尼 exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, 范得他尼 has 1 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 范得他尼?
The CAS number of 范得他尼 is 1174683-49-8.
What is the molecular formula of 范得他尼?
The molecular formula of 范得他尼 is C22H24BrFN4O2.
What is the molecular weight of 范得他尼?
The molecular weight of 范得他尼 is 474.11 g/mol.
Where can I buy 范得他尼?
You can request a quote for 范得他尼 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 范得他尼?
Yes, KEHONG BIO provides custom synthesis services for 范得他尼 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.