吉非替尼
TL;DR: 吉非替尼 (CAS 1173976-40-3) is a chemical compound with molecular formula C22H24ClFN4O3 and molecular weight 446.15 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
吉非替尼
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Also Known As: Gefitinib, Iressa, Irressat, gefitinibum, Tarceva
| Molecular Formula | C22H24ClFN4O3 |
|---|---|
| Molecular Weight | 446.15 g/mol |
| LogP | 4.1 |
| Topological Polar Surface Area | 68.7 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 8 |
| Rotatable Bonds | 8 |
| Exact Mass | 446.1521 |
| Heavy Atoms | 31 |
| Complexity | 545.0 |
| Solubility | Sparingly soluble ( |
Chemical Identifiers
| CAS Number | 1173976-40-3 |
|---|---|
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
| InChIKey | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
Patent-Derived Application Labels
Derived from 12 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
吉非替尼 (CAS 1173976-40-3), with molecular formula C22H24ClFN4O3 and molecular weight 446.15 g/mol. IUPAC: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine.
Chemical Property Profile of 吉非替尼
Property Insights of 吉非替尼
The XLogP value of 4.1 indicates that 吉非替尼 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 68.7 Ų falls within the moderate polarity range, balancing permeability and solubility for 吉非替尼. Following Lipinski's Rule of Five, 吉非替尼 has 1 hydrogen bond donor(s) and 8 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 吉非替尼?
The CAS number of 吉非替尼 is 1173976-40-3.
What is the molecular formula of 吉非替尼?
The molecular formula of 吉非替尼 is C22H24ClFN4O3.
What is the molecular weight of 吉非替尼?
The molecular weight of 吉非替尼 is 446.15 g/mol.
Where can I buy 吉非替尼?
You can request a quote for 吉非替尼 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 吉非替尼?
Yes, KEHONG BIO provides custom synthesis services for 吉非替尼 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.