氯沙坦
TL;DR: 氯沙坦 (CAS 114798-26-4) is a chemical compound with molecular formula C22H23ClN6O and molecular weight 422.16 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
氯沙坦
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Also Known As: losartan, allisartan, Lortaan, Hyzaar, Angizaar
| Molecular Formula | C22H23ClN6O |
|---|---|
| Molecular Weight | 422.16 g/mol |
| LogP | 4.3 |
| Topological Polar Surface Area | 92.5 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 8 |
| Exact Mass | 422.1622 |
| Heavy Atoms | 30 |
| Complexity | 520.0 |
| Melting Point | 178-184 |
| Boiling Point | 682 |
| Solubility | <1mg/mL |
Chemical Identifiers
| CAS Number | 114798-26-4 |
|---|---|
| SMILES | CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl |
| InChIKey | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
Patent-Derived Application Labels
Derived from 15 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
氯沙坦 (CAS 114798-26-4), with molecular formula C22H23ClN6O and molecular weight 422.16 g/mol. IUPAC: [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol.
Chemical Property Profile of 氯沙坦
Property Insights of 氯沙坦
The XLogP value of 4.3 indicates that 氯沙坦鉀 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 92.5 Ų falls within the moderate polarity range, balancing permeability and solubility for 氯沙坦. Following Lipinski's Rule of Five, 氯沙坦鉀 has 2 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 氯沙坦鉀?
The CAS number of 氯沙坦鉀 is 114798-26-4.
What is the molecular formula of 氯沙坦鉀?
The molecular formula of 氯沙坦鉀 is C22H23ClN6O.
What is the molecular weight of 氯沙坦鉀?
The molecular weight of 氯沙坦鉀 is 422.16 g/mol.
Where can I buy 氯沙坦鉀?
You can request a quote for 氯沙坦鉀 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 氯沙坦鉀?
Yes, KEHONG BIO provides custom synthesis services for 氯沙坦鉀 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.