(R)-Topotecan
TL;DR: (R)-Topotecan (CAS 1133355-98-2) is a chemical compound with molecular formula C23H23N3O5 and molecular weight 421.16 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(19R)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
Also Known As: (R)-TOPOTECAN, (19R)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione, (4R)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (R)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione, (R)-Topotecan; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4R)-
| Molecular Formula | C23H23N3O5 |
|---|---|
| Molecular Weight | 421.16 g/mol |
| LogP | 1.8468 |
| Topological Polar Surface Area | 104.89 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 3 |
| Exact Mass | 421.16376 |
| Heavy Atoms | 31 |
| Complexity | 1327.2621 |
Chemical Identifiers
| CAS Number | 1133355-98-2 |
|---|---|
| SMILES | CC[C@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O |
Product Overview
(R)-Topotecan (CAS 1133355-98-2), with molecular formula C23H23N3O5 and molecular weight 421.16 g/mol. IUPAC: (19R)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione.
Chemical Property Profile of (R)-Topotecan
Property Insights of (R)-Topotecan
The XLogP value of 1.8468 suggests moderate lipophilicity, balancing water solubility and membrane permeability for (R)-Topotecan. The TPSA of 104.89 Ų falls within the moderate polarity range, balancing permeability and solubility for (R)-Topotecan. Following Lipinski's Rule of Five, (R)-Topotecan has 2 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of (R)-Topotecan?
The CAS number of (R)-Topotecan is 1133355-98-2.
What is the molecular formula of (R)-Topotecan?
The molecular formula of (R)-Topotecan is C23H23N3O5.
What is the molecular weight of (R)-Topotecan?
The molecular weight of (R)-Topotecan is 421.16 g/mol.
Where can I buy (R)-Topotecan?
You can request a quote for (R)-Topotecan directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for (R)-Topotecan?
Yes, KEHONG BIO provides custom synthesis services for (R)-Topotecan and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.