Lysine-iodosalicylyl-methotrexate structure

Lysine-iodosalicylyl-methotrexate

TL;DR: Lysine-iodosalicylyl-methotrexate (CAS 108919-01-3) is a chemical compound with molecular formula C28H29IN12O5 and molecular weight 738.14 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.

(2S)-6-[(4-azido-2-hydroxy-5-(125I)iodobenzoyl)amino]-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]hexanoic acid

Also Known As: Lysine-iodosalicylyl-methotrexate, N(alpha)-(4-Amino-4-deoxy-10-methylpteroyl)-N(epsilon)-(4-azido-5-iodosalicylyl)lysine, L-Lysine, N6-(4-azido-2-hydroxy-5-(iodo-125I)benzoyl)-N2'-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, N6-(4-Azido-2-hydroxy-5-(iodo-125I)benzoyl)-N2'-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-lysine, (2S)-6-[(4-azido-2-hydroxy-5-(125I)iodanylbenzoyl)amino]-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]hexanoic acid

CAS: 108919-01-3
Molecular Formula C28H29IN12O5
Molecular Weight 738.14 g/mol
LogP 3.2559
Topological Polar Surface Area 271.33 Ų
Hydrogen Bond Donors 6
Hydrogen Bond Acceptors 12
Rotatable Bonds 13
Exact Mass 738.143
Heavy Atoms 46
Complexity 1832.3986

Chemical Identifiers

CAS Number 108919-01-3
SMILES CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCCCNC(=O)C4=CC(=C(C=C4O)N=[N+]=[N-])[125I])C(=O)O

Product Overview

Lysine-iodosalicylyl-methotrexate (CAS 108919-01-3), with molecular formula C28H29IN12O5 and molecular weight 738.14 g/mol. IUPAC: (2S)-6-[(4-azido-2-hydroxy-5-(125I)iodobenzoyl)amino]-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]hexanoic acid.

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Safety Data Sheet (MSDS / SDS) View the Laboratory Chemical Safety Summary (LCSS) on PubChem — includes GHS classifications, hazard statements, first aid measures, and handling precautions.
View MSDS →

Chemical Property Profile of Lysine-iodosalicylyl-methotrexate

XLogP
3.2559
TPSA (Topological Polar Surface Area)
271.33
Hydrogen Bond Donors
6
Hydrogen Bond Acceptors
12
Rotatable Bonds
13
Heavy Atoms
46
Complexity
1832.3986
Exact Mass
738.143
Monoisotopic Mass
738.143
Data Source: Chemical property values are referenced from PubChem, the world's largest open chemistry database maintained by the National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine.

Property Insights of Lysine-iodosalicylyl-methotrexate

The XLogP value of 3.2559 indicates that Lysine-iodosalicylyl-methotrexate is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 271.33 Ų indicates high polarity, suggesting Lysine-iodosalicylyl-methotrexate may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, Lysine-iodosalicylyl-methotrexate has 6 hydrogen bond donor(s) and 12 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.

Frequently Asked Questions

What is the typical lead time for this product?
Lead time typically ranges from 3-7 business days for in-stock items. For larger quantities or custom orders, please contact us for specific lead times.
Can you provide samples for testing?
Yes, we offer sample quantities for quality testing. Please submit an inquiry with your requirements and we will arrange samples accordingly.
What documentation do you provide with the product?
We provide COA (Certificate of Analysis), MSDS (Material Safety Data Sheet), and technical data sheets with each shipment.
Do you ship internationally?
Yes, we ship to most countries worldwide. Shipping costs and delivery times vary by location. Please contact us for specific shipping information.

Frequently Asked Questions

What is the CAS number of Lysine-iodosalicylyl-methotrexate?

The CAS number of Lysine-iodosalicylyl-methotrexate is 108919-01-3.

What is the molecular formula of Lysine-iodosalicylyl-methotrexate?

The molecular formula of Lysine-iodosalicylyl-methotrexate is C28H29IN12O5.

What is the molecular weight of Lysine-iodosalicylyl-methotrexate?

The molecular weight of Lysine-iodosalicylyl-methotrexate is 738.14 g/mol.

Where can I buy Lysine-iodosalicylyl-methotrexate?

You can request a quote for Lysine-iodosalicylyl-methotrexate directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.

Does KEHONG BIO offer custom synthesis for Lysine-iodosalicylyl-methotrexate?

Yes, KEHONG BIO provides custom synthesis services for Lysine-iodosalicylyl-methotrexate and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.

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