Pyroglutamyl-histidyl-proline thioamide
TL;DR: Pyroglutamyl-histidyl-proline thioamide (CAS 99933-27-4) is a chemical compound with molecular formula C16H22N6O3S and molecular weight 378.15 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
N-[1-(2-carbamothioylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Also Known As: Pglu-his-pro-TA, Prot(3)-trh, Pyroglutamyl-histidyl-proline thioamide, 5-Hydroxy-N-[3-(1H-imidazol-5-yl)-1-{2-[imino(sulfanyl)methyl]pyrrolidin-1-yl}-1-oxopropan-2-yl]-3,4-dihydro-2H-pyrrole-2-carboximidic acid, N-[1-(2-carbamothioylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
| Molecular Formula | C16H22N6O3S |
|---|---|
| Molecular Weight | 378.15 g/mol |
| LogP | -1.0073 |
| Topological Polar Surface Area | 133.21 Ų |
| Hydrogen Bond Donors | 4 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 6 |
| Exact Mass | 378.1474 |
| Heavy Atoms | 26 |
| Complexity | 706.8481 |
Chemical Identifiers
| CAS Number | 99933-27-4 |
|---|---|
| SMILES | C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=S)N |
Product Overview
Pyroglutamyl-histidyl-proline thioamide (CAS 99933-27-4), with molecular formula C16H22N6O3S and molecular weight 378.15 g/mol. IUPAC: N-[1-(2-carbamothioylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide.
Chemical Property Profile of Pyroglutamyl-histidyl-proline thioamide
Property Insights of Pyroglutamyl-histidyl-proline thioamide
The XLogP value of -1.0073 indicates that Pyroglutamyl-histidyl-proline thioamide is hydrophilic (water-soluble), making it suitable for aqueous formulations and biological assay applications. The TPSA of 133.21 Ų falls within the moderate polarity range, balancing permeability and solubility for Pyroglutamyl-histidyl-proline thioamide. Following Lipinski's Rule of Five, Pyroglutamyl-histidyl-proline thioamide has 4 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Pyroglutamyl-histidyl-proline thioamide?
The CAS number of Pyroglutamyl-histidyl-proline thioamide is 99933-27-4.
What is the molecular formula of Pyroglutamyl-histidyl-proline thioamide?
The molecular formula of Pyroglutamyl-histidyl-proline thioamide is C16H22N6O3S.
What is the molecular weight of Pyroglutamyl-histidyl-proline thioamide?
The molecular weight of Pyroglutamyl-histidyl-proline thioamide is 378.15 g/mol.
Where can I buy Pyroglutamyl-histidyl-proline thioamide?
You can request a quote for Pyroglutamyl-histidyl-proline thioamide directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Pyroglutamyl-histidyl-proline thioamide?
Yes, KEHONG BIO provides custom synthesis services for Pyroglutamyl-histidyl-proline thioamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.