1,2-Didemethylcolchicine
TL;DR: 1,2-Didemethylcolchicine (CAS 78231-83-1) is a chemical compound with molecular formula C20H21NO6 and molecular weight 371.14 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
N-(1,2-dihydroxy-3,10-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
Also Known As: 1,2-Didemethylcolchicine, Acetamide, N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, N-(1,2-dihydroxy-3,10-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S)-, Acetamide,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
| Molecular Formula | C20H21NO6 |
|---|---|
| Molecular Weight | 371.14 g/mol |
| LogP | 0.2 |
| Topological Polar Surface Area | 105.0 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 3 |
| Exact Mass | 371.1369 |
| Heavy Atoms | 27 |
| Complexity | 709.0 |
Chemical Identifiers
| CAS Number | 78231-83-1 |
|---|---|
| SMILES | CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)O)O)OC |
| InChIKey | QCOIAAVYXNEUDX-UHFFFAOYSA-N |
Product Overview
1,2-Didemethylcolchicine (CAS 78231-83-1), with molecular formula C20H21NO6 and molecular weight 371.14 g/mol. IUPAC: N-(1,2-dihydroxy-3,10-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide.
Chemical Property Profile of 1,2-Didemethylcolchicine
Property Insights of 1,2-Didemethylcolchicine
The XLogP value of 0.2 suggests moderate lipophilicity, balancing water solubility and membrane permeability for 1,2-Didemethylcolchicine. The TPSA of 105.0 Ų falls within the moderate polarity range, balancing permeability and solubility for 1,2-Didemethylcolchicine. Following Lipinski's Rule of Five, 1,2-Didemethylcolchicine has 3 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 1,2-Didemethylcolchicine?
The CAS number of 1,2-Didemethylcolchicine is 78231-83-1.
What is the molecular formula of 1,2-Didemethylcolchicine?
The molecular formula of 1,2-Didemethylcolchicine is C20H21NO6.
What is the molecular weight of 1,2-Didemethylcolchicine?
The molecular weight of 1,2-Didemethylcolchicine is 371.14 g/mol.
Where can I buy 1,2-Didemethylcolchicine?
You can request a quote for 1,2-Didemethylcolchicine directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 1,2-Didemethylcolchicine?
Yes, KEHONG BIO provides custom synthesis services for 1,2-Didemethylcolchicine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.