Cortolone
TL;DR: Cortolone (CAS 77280-85-4) is a chemical compound with molecular formula C21H34O5 and molecular weight 366.24 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1S)-1,2-dihydroxyethyl]-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one
Also Known As: Cortolone, alpha-Cortolone, Cortolon, 20alpha-Cortolone, a-Cortolone
| Molecular Formula | C21H34O5 |
|---|---|
| Molecular Weight | 366.24 g/mol |
| LogP | 1.8 |
| Topological Polar Surface Area | 98.0 Ų |
| Hydrogen Bond Donors | 4 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 2 |
| Exact Mass | 366.24063 |
| Heavy Atoms | 26 |
| Complexity | 593.0 |
Chemical Identifiers
| CAS Number | 77280-85-4 |
|---|---|
| SMILES | C[C@]12CC[C@H](C[C@H]1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4([C@H](CO)O)O)C)O |
| InChIKey | JXCOSKURGJMQSG-AZQJGLEESA-N |
Product Overview
Cortolone (CAS 77280-85-4), with molecular formula C21H34O5 and molecular weight 366.24 g/mol. IUPAC: (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1S)-1,2-dihydroxyethyl]-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one.
Chemical Property Profile of Cortolone
Property Insights of Cortolone
The XLogP value of 1.8 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Cortolone. The TPSA of 98.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Cortolone. Following Lipinski's Rule of Five, Cortolone has 4 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Cortolone?
The CAS number of Cortolone is 77280-85-4.
What is the molecular formula of Cortolone?
The molecular formula of Cortolone is C21H34O5.
What is the molecular weight of Cortolone?
The molecular weight of Cortolone is 366.24 g/mol.
Where can I buy Cortolone?
You can request a quote for Cortolone directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Cortolone?
Yes, KEHONG BIO provides custom synthesis services for Cortolone and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.