5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide
TL;DR: 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide (CAS 76820-40-1) is a chemical compound with molecular formula C18H26N6O4 and molecular weight 390.20 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]-3,3-dimethylpyrrolidine-2-carboxamide
Also Known As: Pyr-his-dmp-NH2, TRH analog, Reckitt & Colman, L-Pyroglutamyl-L-histidyl-3,3-dimethylprolinamide, 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide, SID:81065553
| Molecular Formula | C18H26N6O4 |
|---|---|
| Molecular Weight | 390.20 g/mol |
| LogP | -1.6 |
| Topological Polar Surface Area | 150.0 Ų |
| Hydrogen Bond Donors | 4 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 6 |
| Exact Mass | 390.20154 |
| Heavy Atoms | 28 |
| Complexity | 666.0 |
Chemical Identifiers
| CAS Number | 76820-40-1 |
|---|---|
| SMILES | CC1(CCN([C@@H]1C(=O)N)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C |
| InChIKey | ZEQAPQNFHVYDEL-SGMGOOAPSA-N |
Patent-Derived Application Labels
Derived from 2 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide (CAS 76820-40-1), with molecular formula C18H26N6O4 and molecular weight 390.20 g/mol. IUPAC: (2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]-3,3-dimethylpyrrolidine-2-carboxamide.
Chemical Property Profile of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide
Property Insights of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide
The XLogP value of -1.6 indicates that 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide is hydrophilic (water-soluble), making it suitable for aqueous formulations and biological assay applications. The TPSA of 150.0 Ų indicates high polarity, suggesting 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide has 4 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide?
The CAS number of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide is 76820-40-1.
What is the molecular formula of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide?
The molecular formula of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide is C18H26N6O4.
What is the molecular weight of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide?
The molecular weight of 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide is 390.20 g/mol.
Where can I buy 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide?
You can request a quote for 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide?
Yes, KEHONG BIO provides custom synthesis services for 5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.