Tivozanib
TL;DR: Tivozanib (CAS 682745-41-1) is a chemical compound with molecular formula C22H19ClN4O5 and molecular weight 454.10 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
Also Known As: Tivozanib, Tivozanib (AV-951), fotivda, tivozanibum, Tivozanib [USAN]
| Molecular Formula | C22H19ClN4O5 |
|---|---|
| Molecular Weight | 454.10 g/mol |
| LogP | 5.63812 |
| Topological Polar Surface Area | 107.74 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 6 |
| Exact Mass | 454.1044 |
| Heavy Atoms | 32 |
| Complexity | 1290.7979 |
Chemical Identifiers
| CAS Number | 682745-41-1 |
|---|---|
| SMILES | CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl |
Product Overview
Tivozanib (CAS 682745-41-1), with molecular formula C22H19ClN4O5 and molecular weight 454.10 g/mol. IUPAC: 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea.
Chemical Property Profile of Tivozanib
Property Insights of Tivozanib
The XLogP value of 5.63812 indicates that Tivozanib is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 107.74 Ų falls within the moderate polarity range, balancing permeability and solubility for Tivozanib. Following Lipinski's Rule of Five, Tivozanib has 2 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Tivozanib?
The CAS number of Tivozanib is 682745-41-1.
What is the molecular formula of Tivozanib?
The molecular formula of Tivozanib is C22H19ClN4O5.
What is the molecular weight of Tivozanib?
The molecular weight of Tivozanib is 454.10 g/mol.
Where can I buy Tivozanib?
You can request a quote for Tivozanib directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Tivozanib?
Yes, KEHONG BIO provides custom synthesis services for Tivozanib and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.