Promethazine Hydrochloride
TL;DR: Promethazine Hydrochloride (CAS 58-33-3) is a chemical compound with molecular formula C17H21ClN2S and molecular weight 320.11 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride
Also Known As: PROMETHAZINE HYDROCHLORIDE, Promethazine Hcl, Phenergan, Remsed, Promethacon
| Molecular Formula | C17H21ClN2S |
|---|---|
| Molecular Weight | 320.11 g/mol |
| LogP | 4.66 |
| Topological Polar Surface Area | 31.8 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 3 |
| Exact Mass | 320.1114 |
| Heavy Atoms | 21 |
| Complexity | 298.0 |
| Melting Point | 446 to 232.2 °C (decomposes) |
| Solubility | greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) |
Chemical Identifiers
| CAS Number | 58-33-3 |
|---|---|
| SMILES | CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
Patent-Derived Application Labels
Derived from 19 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
Promethazine Hydrochloride (CAS 58-33-3), with molecular formula C17H21ClN2S and molecular weight 320.11 g/mol. IUPAC: N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride.
Chemical Property Profile of Promethazine Hydrochloride
Property Insights of Promethazine Hydrochloride
The XLogP value of 4.66 indicates that Promethazine Hydrochloride is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 31.8 Ų, Promethazine Hydrochloride exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Promethazine Hydrochloride has 1 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Promethazine Hydrochloride?
The CAS number of Promethazine Hydrochloride is 58-33-3.
What is the molecular formula of Promethazine Hydrochloride?
The molecular formula of Promethazine Hydrochloride is C17H21ClN2S.
What is the molecular weight of Promethazine Hydrochloride?
The molecular weight of Promethazine Hydrochloride is 320.11 g/mol.
Where can I buy Promethazine Hydrochloride?
You can request a quote for Promethazine Hydrochloride directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Promethazine Hydrochloride?
Yes, KEHONG BIO provides custom synthesis services for Promethazine Hydrochloride and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.