Avatrombopag
TL;DR: Avatrombopag (CAS 570409-64-2) is a chemical compound with molecular formula C29H34Cl2N6O3S2 and molecular weight 648.15 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]-2-pyridinyl]piperidine-4-carboxylic acid
Also Known As: AVATROMBOPAG, Doptelet, avatrombopagum, Avatrombopag free base, Avatrombopag [USAN]
| Molecular Formula | C29H34Cl2N6O3S2 |
|---|---|
| Molecular Weight | 648.15 g/mol |
| LogP | 6.5814 |
| Topological Polar Surface Area | 101.9 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 9 |
| Rotatable Bonds | 7 |
| Exact Mass | 648.15106 |
| Heavy Atoms | 42 |
| Complexity | 1426.339 |
Chemical Identifiers
| CAS Number | 570409-64-2 |
|---|---|
| SMILES | C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl |
Product Overview
Avatrombopag (CAS 570409-64-2), with molecular formula C29H34Cl2N6O3S2 and molecular weight 648.15 g/mol. IUPAC: 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]-2-pyridinyl]piperidine-4-carboxylic acid.
Chemical Property Profile of Avatrombopag
Property Insights of Avatrombopag
The XLogP value of 6.5814 indicates that Avatrombopag is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 101.9 Ų falls within the moderate polarity range, balancing permeability and solubility for Avatrombopag. Following Lipinski's Rule of Five, Avatrombopag has 2 hydrogen bond donor(s) and 9 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Avatrombopag?
The CAS number of Avatrombopag is 570409-64-2.
What is the molecular formula of Avatrombopag?
The molecular formula of Avatrombopag is C29H34Cl2N6O3S2.
What is the molecular weight of Avatrombopag?
The molecular weight of Avatrombopag is 648.15 g/mol.
Where can I buy Avatrombopag?
You can request a quote for Avatrombopag directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Avatrombopag?
Yes, KEHONG BIO provides custom synthesis services for Avatrombopag and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.