Indomethacin, TMS derivative
TL;DR: Indomethacin, TMS derivative (CAS 55334-98-0) is a chemical compound with molecular formula C22H24ClNO4Si and molecular weight 429.12 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
trimethylsilyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate
Also Known As: Indomethacin, TMS derivative, Indomethacin, trimethylsilyl ester, Trimethylsilyl ester of Indomethacin, Monotrimethylsilyl derivative of Indomethacin, 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid trimethylsilyl ester
| Molecular Formula | C22H24ClNO4Si |
|---|---|
| Molecular Weight | 429.12 g/mol |
| LogP | 5.22082 |
| Topological Polar Surface Area | 57.5 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 6 |
| Exact Mass | 429.1163 |
| Heavy Atoms | 29 |
| Complexity | 602.0 |
Chemical Identifiers
| CAS Number | 55334-98-0 |
|---|---|
| SMILES | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O[Si](C)(C)C |
| InChIKey | IIVAVCYZYUDGAS-UHFFFAOYSA-N |
Product Overview
Indomethacin, TMS derivative (CAS 55334-98-0), with molecular formula C22H24ClNO4Si and molecular weight 429.12 g/mol. IUPAC: trimethylsilyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate.
Chemical Property Profile of Indomethacin, TMS derivative
Property Insights of Indomethacin, TMS derivative
The XLogP value of 5.22082 indicates that Indomethacin, TMS derivative is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 57.5 Ų, Indomethacin, TMS derivative exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Indomethacin, TMS derivative has 0 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Indomethacin, TMS derivative?
The CAS number of Indomethacin, TMS derivative is 55334-98-0.
What is the molecular formula of Indomethacin, TMS derivative?
The molecular formula of Indomethacin, TMS derivative is C22H24ClNO4Si.
What is the molecular weight of Indomethacin, TMS derivative?
The molecular weight of Indomethacin, TMS derivative is 429.12 g/mol.
Where can I buy Indomethacin, TMS derivative?
You can request a quote for Indomethacin, TMS derivative directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Indomethacin, TMS derivative?
Yes, KEHONG BIO provides custom synthesis services for Indomethacin, TMS derivative and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.