Givinostat
TL;DR: Givinostat (CAS 497834-68-1) is a chemical compound with molecular formula C24H27N3O4 and molecular weight 421.20 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
Also Known As: Givinostat, Gavinostat, Givinostat [INN], givinostatum, Givinostat free base
| Molecular Formula | C24H27N3O4 |
|---|---|
| Molecular Weight | 421.20 g/mol |
| LogP | 4.5493 |
| Topological Polar Surface Area | 90.9 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 8 |
| Exact Mass | 421.20016 |
| Heavy Atoms | 31 |
| Complexity | 1046.3787 |
Chemical Identifiers
| CAS Number | 497834-68-1 |
|---|---|
| SMILES | CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO |
Product Overview
Givinostat (CAS 497834-68-1), with molecular formula C24H27N3O4 and molecular weight 421.20 g/mol. IUPAC: [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate.
Chemical Property Profile of Givinostat
Property Insights of Givinostat
The XLogP value of 4.5493 indicates that Givinostat is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 90.9 Ų falls within the moderate polarity range, balancing permeability and solubility for Givinostat. Following Lipinski's Rule of Five, Givinostat has 3 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Givinostat?
The CAS number of Givinostat is 497834-68-1.
What is the molecular formula of Givinostat?
The molecular formula of Givinostat is C24H27N3O4.
What is the molecular weight of Givinostat?
The molecular weight of Givinostat is 421.20 g/mol.
Where can I buy Givinostat?
You can request a quote for Givinostat directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Givinostat?
Yes, KEHONG BIO provides custom synthesis services for Givinostat and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.