(E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide
TL;DR: (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide (CAS 468769-36-0) is a chemical compound with molecular formula C21H16FN3OS and molecular weight 377.10 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(E)-2-cyano-N-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-methylphenyl)prop-2-enamide
Also Known As: (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide, F1589-1534, (2E)-2-CYANO-N-{5-[(4-FLUOROPHENYL)METHYL]-1,3-THIAZOL-2-YL}-3-(2-METHYLPHENYL)PROP-2-ENAMIDE, (2E)-2-cyano-N-[5-(4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-methylphenyl)prop-2-enamide, (2E)-2-cyano-N-{5-[(4-fluorophenyl)methyl](1,3-thiazol-2-yl)}-3-(2-methylpheny l)prop-2-enamide
| Molecular Formula | C21H16FN3OS |
|---|---|
| Molecular Weight | 377.10 g/mol |
| LogP | 4.7271 |
| Topological Polar Surface Area | 65.78 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 5 |
| Exact Mass | 377.09982 |
| Heavy Atoms | 27 |
| Complexity | 1032.0803 |
Chemical Identifiers
| CAS Number | 468769-36-0 |
|---|---|
| SMILES | CC1=CC=CC=C1/C=C(\C#N)/C(=O)NC2=NC=C(S2)CC3=CC=C(C=C3)F |
Product Overview
(E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide (CAS 468769-36-0), with molecular formula C21H16FN3OS and molecular weight 377.10 g/mol. IUPAC: (E)-2-cyano-N-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-methylphenyl)prop-2-enamide.
Chemical Property Profile of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide
Property Insights of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide
The XLogP value of 4.7271 indicates that (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 65.78 Ų falls within the moderate polarity range, balancing permeability and solubility for (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide. Following Lipinski's Rule of Five, (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide has 1 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide?
The CAS number of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide is 468769-36-0.
What is the molecular formula of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide?
The molecular formula of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide is C21H16FN3OS.
What is the molecular weight of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide?
The molecular weight of (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide is 377.10 g/mol.
Where can I buy (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide?
You can request a quote for (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide?
Yes, KEHONG BIO provides custom synthesis services for (E)-2-cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.