AFP-464 free base
TL;DR: AFP-464 free base (CAS 468719-52-0) is a chemical compound with molecular formula C22H23F3N4O3 and molecular weight 448.17 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(2S)-2,6-diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide
Also Known As: AFP-464 free base, AFP464 free base, AFP464 (free base), 468719-52-0 (free base), NCI60_038882
| Molecular Formula | C22H23F3N4O3 |
|---|---|
| Molecular Weight | 448.17 g/mol |
| LogP | 2.1 |
| Topological Polar Surface Area | 133.0 Ų |
| Hydrogen Bond Donors | 4 |
| Hydrogen Bond Acceptors | 9 |
| Rotatable Bonds | 7 |
| Exact Mass | 448.1722 |
| Heavy Atoms | 32 |
| Complexity | 725.0 |
Chemical Identifiers
| CAS Number | 468719-52-0 |
|---|---|
| SMILES | CC1=C(C(=C2C(=O)C=C(OC2=C1F)C3=CC(=C(C=C3)NC(=O)[C@H](CCCCN)N)F)N)F |
| InChIKey | WHWJKUICJXPKFQ-ZDUSSCGKSA-N |
Patent-Derived Application Labels
Derived from 2 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
AFP-464 free base (CAS 468719-52-0), with molecular formula C22H23F3N4O3 and molecular weight 448.17 g/mol. IUPAC: (2S)-2,6-diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide.
Chemical Property Profile of AFP-464 free base
Property Insights of AFP-464 free base
The XLogP value of 2.1 suggests moderate lipophilicity, balancing water solubility and membrane permeability for AFP-464 free base. The TPSA of 133.0 Ų falls within the moderate polarity range, balancing permeability and solubility for AFP-464 free base. Following Lipinski's Rule of Five, AFP-464 free base has 4 hydrogen bond donor(s) and 9 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of AFP-464 free base?
The CAS number of AFP-464 free base is 468719-52-0.
What is the molecular formula of AFP-464 free base?
The molecular formula of AFP-464 free base is C22H23F3N4O3.
What is the molecular weight of AFP-464 free base?
The molecular weight of AFP-464 free base is 448.17 g/mol.
Where can I buy AFP-464 free base?
You can request a quote for AFP-464 free base directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for AFP-464 free base?
Yes, KEHONG BIO provides custom synthesis services for AFP-464 free base and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.