18-Hydroxycortisone
TL;DR: 18-Hydroxycortisone (CAS 4087-07-4) is a chemical compound with molecular formula C21H28O6 and molecular weight 376.19 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
Also Known As: 18-Hydroxycortisone, 17,18,21-Trihydroxy-4-pregnene-3,11,20-trione, 17,18,21-Trihydroxypregn-4-ene-3,11,20-trione, Pregn-4-ene-3,11,20-trione, 17,18,21-trihydroxy-, (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
| Molecular Formula | C21H28O6 |
|---|---|
| Molecular Weight | 376.19 g/mol |
| LogP | 0.2 |
| Topological Polar Surface Area | 112.0 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 3 |
| Exact Mass | 376.1886 |
| Heavy Atoms | 27 |
| Complexity | 741.0 |
Chemical Identifiers
| CAS Number | 4087-07-4 |
|---|---|
| SMILES | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)CO |
| InChIKey | FPYGQPQXGSIDSF-RBWSHPMZSA-N |
Patent-Derived Application Labels
Derived from 2 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
18-Hydroxycortisone (CAS 4087-07-4), with molecular formula C21H28O6 and molecular weight 376.19 g/mol. IUPAC: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione.
Chemical Property Profile of 18-Hydroxycortisone
Property Insights of 18-Hydroxycortisone
The XLogP value of 0.2 suggests moderate lipophilicity, balancing water solubility and membrane permeability for 18-Hydroxycortisone. The TPSA of 112.0 Ų falls within the moderate polarity range, balancing permeability and solubility for 18-Hydroxycortisone. Following Lipinski's Rule of Five, 18-Hydroxycortisone has 3 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 18-Hydroxycortisone?
The CAS number of 18-Hydroxycortisone is 4087-07-4.
What is the molecular formula of 18-Hydroxycortisone?
The molecular formula of 18-Hydroxycortisone is C21H28O6.
What is the molecular weight of 18-Hydroxycortisone?
The molecular weight of 18-Hydroxycortisone is 376.19 g/mol.
Where can I buy 18-Hydroxycortisone?
You can request a quote for 18-Hydroxycortisone directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 18-Hydroxycortisone?
Yes, KEHONG BIO provides custom synthesis services for 18-Hydroxycortisone and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.