5'-O-(tert-butyldimethylsilyl)-thymidine
TL;DR: 5'-O-(tert-butyldimethylsilyl)-thymidine (CAS 40733-28-6) is a chemical compound with molecular formula C16H28N2O5Si and molecular weight 356.18 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
1-[5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
Also Known As: Thymidine, 5'-O-TBDMS, 5'-O-TBDMS-dT, 5'-O-(tert-butyldimethylsilyl)-thymidine, 5'-O-tert-Butyldimethylsilylthymidine, 5'-O-TERT-BUTYLDIMETHYLSILYL-THYMIDINE
| Molecular Formula | C16H28N2O5Si |
|---|---|
| Molecular Weight | 356.18 g/mol |
| LogP | 1.51522 |
| Topological Polar Surface Area | 88.1 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 5 |
| Exact Mass | 356.17676 |
| Heavy Atoms | 24 |
| Complexity | 555.0 |
Chemical Identifiers
| CAS Number | 40733-28-6 |
|---|---|
| SMILES | CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO[Si](C)(C)C(C)(C)C)O |
| InChIKey | IJWIJLIIOKZJMS-UHFFFAOYSA-N |
Product Overview
5'-O-(tert-butyldimethylsilyl)-thymidine (CAS 40733-28-6), with molecular formula C16H28N2O5Si and molecular weight 356.18 g/mol. IUPAC: 1-[5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione.
Chemical Property Profile of 5'-O-(tert-butyldimethylsilyl)-thymidine
Property Insights of 5'-O-(tert-butyldimethylsilyl)-thymidine
The XLogP value of 1.51522 suggests moderate lipophilicity, balancing water solubility and membrane permeability for 5'-O-(tert-butyldimethylsilyl)-thymidine. The TPSA of 88.1 Ų falls within the moderate polarity range, balancing permeability and solubility for 5'-O-(tert-butyldimethylsilyl)-thymidine. Following Lipinski's Rule of Five, 5'-O-(tert-butyldimethylsilyl)-thymidine has 2 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 5'-O-(tert-butyldimethylsilyl)-thymidine?
The CAS number of 5'-O-(tert-butyldimethylsilyl)-thymidine is 40733-28-6.
What is the molecular formula of 5'-O-(tert-butyldimethylsilyl)-thymidine?
The molecular formula of 5'-O-(tert-butyldimethylsilyl)-thymidine is C16H28N2O5Si.
What is the molecular weight of 5'-O-(tert-butyldimethylsilyl)-thymidine?
The molecular weight of 5'-O-(tert-butyldimethylsilyl)-thymidine is 356.18 g/mol.
Where can I buy 5'-O-(tert-butyldimethylsilyl)-thymidine?
You can request a quote for 5'-O-(tert-butyldimethylsilyl)-thymidine directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 5'-O-(tert-butyldimethylsilyl)-thymidine?
Yes, KEHONG BIO provides custom synthesis services for 5'-O-(tert-butyldimethylsilyl)-thymidine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.