(E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile
TL;DR: (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile (CAS 378205-77-7) is a chemical compound with molecular formula C19H12ClF2N3OS and molecular weight 403.04 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(E)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[2-(difluoromethoxy)anilino]prop-2-enenitrile
Also Known As: (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile, (2E)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-{[2-(difluoromethoxy)phenyl]amino}prop-2-enenitrile, (E)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[2-(difluoromethoxy)anilino]prop-2-enenitrile
| Molecular Formula | C19H12ClF2N3OS |
|---|---|
| Molecular Weight | 403.04 g/mol |
| LogP | 6.04148 |
| Topological Polar Surface Area | 57.94 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 6 |
| Exact Mass | 403.03577 |
| Heavy Atoms | 27 |
| Complexity | 996.6894 |
Chemical Identifiers
| CAS Number | 378205-77-7 |
|---|---|
| SMILES | C1=CC=C(C(=C1)N/C=C(\C#N)/C2=NC(=CS2)C3=CC=C(C=C3)Cl)OC(F)F |
Product Overview
(E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile (CAS 378205-77-7), with molecular formula C19H12ClF2N3OS and molecular weight 403.04 g/mol. IUPAC: (E)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[2-(difluoromethoxy)anilino]prop-2-enenitrile.
Chemical Property Profile of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile
Property Insights of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile
The XLogP value of 6.04148 indicates that (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 57.94 Ų, (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile has 1 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile?
The CAS number of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile is 378205-77-7.
What is the molecular formula of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile?
The molecular formula of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile is C19H12ClF2N3OS.
What is the molecular weight of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile?
The molecular weight of (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile is 403.04 g/mol.
Where can I buy (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile?
You can request a quote for (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile?
Yes, KEHONG BIO provides custom synthesis services for (E)-2-(4-(4-chlorophenyl)thiazol-2-yl)-3-((2-(difluoromethoxy)phenyl)amino)acrylonitrile and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.