Folaprim
TL;DR: Folaprim (CAS 37357-69-0) is a chemical compound with molecular formula C24H25ClN6O2S and molecular weight 496.14 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
4-(4-aminophenyl)sulfonylaniline;5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
Also Known As: Folaprim, Maloprim, Deltaprim, Maloprime, Dapsone & Pyrimethamine
| Molecular Formula | C24H25ClN6O2S |
|---|---|
| Molecular Weight | 496.14 g/mol |
| LogP | 4.21 |
| Topological Polar Surface Area | 172.0 Ų |
| Hydrogen Bond Donors | 4 |
| Hydrogen Bond Acceptors | 8 |
| Rotatable Bonds | 4 |
| Exact Mass | 496.14484 |
| Heavy Atoms | 34 |
| Complexity | 549.0 |
Chemical Identifiers
| CAS Number | 37357-69-0 |
|---|---|
| SMILES | CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl.C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N |
| InChIKey | DPHWJXXMMQWNKS-UHFFFAOYSA-N |
Product Overview
Folaprim (CAS 37357-69-0), with molecular formula C24H25ClN6O2S and molecular weight 496.14 g/mol. IUPAC: 4-(4-aminophenyl)sulfonylaniline;5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine.
Chemical Property Profile of Folaprim
Property Insights of Folaprim
The XLogP value of 4.21 indicates that Folaprim is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 172.0 Ų indicates high polarity, suggesting Folaprim may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, Folaprim has 4 hydrogen bond donor(s) and 8 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Folaprim?
The CAS number of Folaprim is 37357-69-0.
What is the molecular formula of Folaprim?
The molecular formula of Folaprim is C24H25ClN6O2S.
What is the molecular weight of Folaprim?
The molecular weight of Folaprim is 496.14 g/mol.
Where can I buy Folaprim?
You can request a quote for Folaprim directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Folaprim?
Yes, KEHONG BIO provides custom synthesis services for Folaprim and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.