N-Desmethyl rosuvastatin
TL;DR: N-Desmethyl rosuvastatin (CAS 371775-74-5) is a chemical compound with molecular formula C21H26FN3O6S and molecular weight 467.15 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(E,3R,5S)-7-[4-(4-fluorophenyl)-2-(methanesulfonamido)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
Also Known As: N-Desmethyl rosuvastatin, N-Desmethylrosuvastatin, DM-RST, N-DESMETHYL ROSUVASTATIN-D3, 371775-74-5(free base)
| Molecular Formula | C21H26FN3O6S |
|---|---|
| Molecular Weight | 467.15 g/mol |
| LogP | 2.3774 |
| Topological Polar Surface Area | 149.71 Ų |
| Hydrogen Bond Donors | 4 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 10 |
| Exact Mass | 467.15265 |
| Heavy Atoms | 32 |
| Complexity | 1087.459 |
Chemical Identifiers
| CAS Number | 371775-74-5 |
|---|---|
| SMILES | CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)NS(=O)(=O)C |
Product Overview
N-Desmethyl rosuvastatin (CAS 371775-74-5), with molecular formula C21H26FN3O6S and molecular weight 467.15 g/mol. IUPAC: (E,3R,5S)-7-[4-(4-fluorophenyl)-2-(methanesulfonamido)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid.
Chemical Property Profile of N-Desmethyl rosuvastatin
Property Insights of N-Desmethyl rosuvastatin
The XLogP value of 2.3774 suggests moderate lipophilicity, balancing water solubility and membrane permeability for N-Desmethyl rosuvastatin. The TPSA of 149.71 Ų indicates high polarity, suggesting N-Desmethyl rosuvastatin may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, N-Desmethyl rosuvastatin has 4 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of N-Desmethyl rosuvastatin?
The CAS number of N-Desmethyl rosuvastatin is 371775-74-5.
What is the molecular formula of N-Desmethyl rosuvastatin?
The molecular formula of N-Desmethyl rosuvastatin is C21H26FN3O6S.
What is the molecular weight of N-Desmethyl rosuvastatin?
The molecular weight of N-Desmethyl rosuvastatin is 467.15 g/mol.
Where can I buy N-Desmethyl rosuvastatin?
You can request a quote for N-Desmethyl rosuvastatin directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for N-Desmethyl rosuvastatin?
Yes, KEHONG BIO provides custom synthesis services for N-Desmethyl rosuvastatin and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.