(E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide
TL;DR: (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide (CAS 355395-36-7) is a chemical compound with molecular formula C24H18ClFN4O4 and molecular weight 480.10 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
N-[(E)-[4-(2-chloro-5-fluoropyrimidin-4-yl)oxy-3-ethoxyphenyl]methylideneamino]-3-hydroxynaphthalene-2-carboxamide
Also Known As: (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide, N'-[(E)-{4-[(2-chloro-5-fluoropyrimidin-4-yl)oxy]-3-ethoxyphenyl}methylidene]-3-hydroxynaphthalene-2-carbohydrazide, N-[(E)-[4-(2-chloro-5-fluoropyrimidin-4-yl)oxy-3-ethoxyphenyl]methylideneamino]-3-hydroxynaphthalene-2-carboxamide, N-{(1E)-2-[4-(2-chloro-5-fluoropyrimidin-4-yloxy)-3-ethoxyphenyl]-1-azavinyl}( 3-hydroxy(2-naphthyl))carboxamide
| Molecular Formula | C24H18ClFN4O4 |
|---|---|
| Molecular Weight | 480.10 g/mol |
| LogP | 5.0828 |
| Topological Polar Surface Area | 105.93 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 7 |
| Exact Mass | 480.10007 |
| Heavy Atoms | 34 |
| Complexity | 1397.0216 |
Chemical Identifiers
| CAS Number | 355395-36-7 |
|---|---|
| SMILES | CCOC1=C(C=CC(=C1)/C=N/NC(=O)C2=CC3=CC=CC=C3C=C2O)OC4=NC(=NC=C4F)Cl |
Product Overview
(E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide (CAS 355395-36-7), with molecular formula C24H18ClFN4O4 and molecular weight 480.10 g/mol. IUPAC: N-[(E)-[4-(2-chloro-5-fluoropyrimidin-4-yl)oxy-3-ethoxyphenyl]methylideneamino]-3-hydroxynaphthalene-2-carboxamide.
Chemical Property Profile of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide
Property Insights of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide
The XLogP value of 5.0828 indicates that (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 105.93 Ų falls within the moderate polarity range, balancing permeability and solubility for (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide. Following Lipinski's Rule of Five, (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide has 2 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide?
The CAS number of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide is 355395-36-7.
What is the molecular formula of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide?
The molecular formula of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide is C24H18ClFN4O4.
What is the molecular weight of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide?
The molecular weight of (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide is 480.10 g/mol.
Where can I buy (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide?
You can request a quote for (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide?
Yes, KEHONG BIO provides custom synthesis services for (E)-N'-(4-((2-chloro-5-fluoropyrimidin-4-yl)oxy)-3-ethoxybenzylidene)-3-hydroxy-2-naphthohydrazide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.