BMS-A78277
TL;DR: BMS-A78277 (CAS 335448-58-3) is a chemical compound with molecular formula C17H14F4N2O2 and molecular weight 354.10 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(5S)-5-(cyclopropylmethoxy)-7-fluoro-1-hydroxy-5-(trifluoromethyl)benzo[b][1,8]naphthyridine
Also Known As: BMS-A78277, DPC-A78277, DPC-A-78277, (5S)-5-(Cyclopropylmethoxy)-7-fluoro-5-(trifluoromethyl)-10H-benzo(g)(1,8)naphthyridine 1-oxide, Benzo(b)(1,8)naphthyridine, 5-(cyclopropylmethoxy)-7-fluoro-5,10-dihydro-5-(trifluoromethyl)-, 1-oxide, (5S)-
| Molecular Formula | C17H14F4N2O2 |
|---|---|
| Molecular Weight | 354.10 g/mol |
| LogP | 4.1984 |
| Topological Polar Surface Area | 45.06 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 3 |
| Exact Mass | 354.09915 |
| Heavy Atoms | 25 |
| Complexity | 811.35614 |
Chemical Identifiers
| CAS Number | 335448-58-3 |
|---|---|
| SMILES | C1CC1CO[C@@]2(C3=CC=CN(C3=NC4=C2C=C(C=C4)F)O)C(F)(F)F |
Product Overview
BMS-A78277 (CAS 335448-58-3), with molecular formula C17H14F4N2O2 and molecular weight 354.10 g/mol. IUPAC: (5S)-5-(cyclopropylmethoxy)-7-fluoro-1-hydroxy-5-(trifluoromethyl)benzo[b][1,8]naphthyridine.
Chemical Property Profile of BMS-A78277
Property Insights of BMS-A78277
The XLogP value of 4.1984 indicates that BMS-A78277 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 45.06 Ų, BMS-A78277 exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, BMS-A78277 has 1 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of BMS-A78277?
The CAS number of BMS-A78277 is 335448-58-3.
What is the molecular formula of BMS-A78277?
The molecular formula of BMS-A78277 is C17H14F4N2O2.
What is the molecular weight of BMS-A78277?
The molecular weight of BMS-A78277 is 354.10 g/mol.
Where can I buy BMS-A78277?
You can request a quote for BMS-A78277 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for BMS-A78277?
Yes, KEHONG BIO provides custom synthesis services for BMS-A78277 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.