KRN 633
TL;DR: KRN 633 (CAS 286370-15-8) is a chemical compound with molecular formula C20H21ClN4O4 and molecular weight 416.13 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea
Also Known As: KRN 633, KRN633, -propylurea, K00589a, VEGF receptor tyrosine kinase inhibitor III
| Molecular Formula | C20H21ClN4O4 |
|---|---|
| Molecular Weight | 416.13 g/mol |
| LogP | 4.6242 |
| Topological Polar Surface Area | 94.6 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 7 |
| Exact Mass | 416.12512 |
| Heavy Atoms | 29 |
| Complexity | 1028.7789 |
Chemical Identifiers
| CAS Number | 286370-15-8 |
|---|---|
| SMILES | CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl |
Product Overview
KRN 633 (CAS 286370-15-8), with molecular formula C20H21ClN4O4 and molecular weight 416.13 g/mol. IUPAC: 1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea.
Chemical Property Profile of KRN 633
Property Insights of KRN 633
The XLogP value of 4.6242 indicates that KRN 633 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 94.6 Ų falls within the moderate polarity range, balancing permeability and solubility for KRN 633. Following Lipinski's Rule of Five, KRN 633 has 2 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of KRN 633?
The CAS number of KRN 633 is 286370-15-8.
What is the molecular formula of KRN 633?
The molecular formula of KRN 633 is C20H21ClN4O4.
What is the molecular weight of KRN 633?
The molecular weight of KRN 633 is 416.13 g/mol.
Where can I buy KRN 633?
You can request a quote for KRN 633 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for KRN 633?
Yes, KEHONG BIO provides custom synthesis services for KRN 633 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.