Lofepramine Hydrochloride
TL;DR: Lofepramine Hydrochloride (CAS 26786-32-3) is a chemical compound with molecular formula C26H28Cl2N2O and molecular weight 454.16 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone;hydrochloride
Also Known As: lofepramine hydrochloride, Gamonil, Lofepramine HCl, Amplit, Gamanil
| Molecular Formula | C26H28Cl2N2O |
|---|---|
| Molecular Weight | 454.16 g/mol |
| LogP | 6.2 |
| Topological Polar Surface Area | 23.6 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 7 |
| Exact Mass | 454.15787 |
| Heavy Atoms | 31 |
| Complexity | 523.0 |
Chemical Identifiers
| CAS Number | 26786-32-3 |
|---|---|
| SMILES | CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl.Cl |
| InChIKey | ZWZIQPOLMDPIQM-UHFFFAOYSA-N |
Patent-Derived Application Labels
Derived from 7 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
Lofepramine Hydrochloride (CAS 26786-32-3), with molecular formula C26H28Cl2N2O and molecular weight 454.16 g/mol. IUPAC: 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone;hydrochloride.
Chemical Property Profile of Lofepramine Hydrochloride
Property Insights of Lofepramine Hydrochloride
The XLogP value of 6.2 indicates that Lofepramine Hydrochloride is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 23.6 Ų, Lofepramine Hydrochloride exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Lofepramine Hydrochloride has 1 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Lofepramine Hydrochloride?
The CAS number of Lofepramine Hydrochloride is 26786-32-3.
What is the molecular formula of Lofepramine Hydrochloride?
The molecular formula of Lofepramine Hydrochloride is C26H28Cl2N2O.
What is the molecular weight of Lofepramine Hydrochloride?
The molecular weight of Lofepramine Hydrochloride is 454.16 g/mol.
Where can I buy Lofepramine Hydrochloride?
You can request a quote for Lofepramine Hydrochloride directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Lofepramine Hydrochloride?
Yes, KEHONG BIO provides custom synthesis services for Lofepramine Hydrochloride and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.