Awd 12-281
TL;DR: Awd 12-281 (CAS 257892-33-4) is a chemical compound with molecular formula C22H14Cl2FN3O3 and molecular weight 457.04 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
N-(3,5-dichloro-4-pyridinyl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide
Also Known As: awd12-281, N-(3,5-dichloropyrid-4-yl)-(1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl)glyoxylic acid amide, SID:53790282, AWD 12-281; GSK 842470, J1.525.747D
| Molecular Formula | C22H14Cl2FN3O3 |
|---|---|
| Molecular Weight | 457.04 g/mol |
| LogP | 5.0575 |
| Topological Polar Surface Area | 84.22 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 5 |
| Exact Mass | 457.0396 |
| Heavy Atoms | 31 |
| Complexity | 1299.5829 |
Chemical Identifiers
| CAS Number | 257892-33-4 |
|---|---|
| SMILES | C1=CC(=CC=C1CN2C=C(C3=C2C=CC(=C3)O)C(=O)C(=O)NC4=C(C=NC=C4Cl)Cl)F |
Product Overview
Awd 12-281 (CAS 257892-33-4), with molecular formula C22H14Cl2FN3O3 and molecular weight 457.04 g/mol. IUPAC: N-(3,5-dichloro-4-pyridinyl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide.
Chemical Property Profile of Awd 12-281
Property Insights of Awd 12-281
The XLogP value of 5.0575 indicates that Awd 12-281 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 84.22 Ų falls within the moderate polarity range, balancing permeability and solubility for Awd 12-281. Following Lipinski's Rule of Five, Awd 12-281 has 2 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Awd 12-281?
The CAS number of Awd 12-281 is 257892-33-4.
What is the molecular formula of Awd 12-281?
The molecular formula of Awd 12-281 is C22H14Cl2FN3O3.
What is the molecular weight of Awd 12-281?
The molecular weight of Awd 12-281 is 457.04 g/mol.
Where can I buy Awd 12-281?
You can request a quote for Awd 12-281 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Awd 12-281?
Yes, KEHONG BIO provides custom synthesis services for Awd 12-281 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.