Lofexidine Hydrochloride
TL;DR: Lofexidine Hydrochloride (CAS 21498-08-8) is a chemical compound with molecular formula C11H13Cl3N2O and molecular weight 294.01 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride
Also Known As: Lofexidine hydrochloride, LOFEXIDINE HCl, Lofetensin, Britlofex, Lofexidine
| Molecular Formula | C11H13Cl3N2O |
|---|---|
| Molecular Weight | 294.01 g/mol |
| LogP | 3.18 |
| Topological Polar Surface Area | 33.6 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 2 |
| Rotatable Bonds | 3 |
| Exact Mass | 294.00934 |
| Heavy Atoms | 17 |
| Complexity | 263.0 |
Chemical Identifiers
| CAS Number | 21498-08-8 |
|---|---|
| SMILES | CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl.Cl |
| InChIKey | DWWHMKBNNNZGHF-UHFFFAOYSA-N |
Patent-Derived Application Labels
Derived from 3 IPC patent classification(s) across the SureChEMBL global patent database.
Product Overview
Lofexidine Hydrochloride (CAS 21498-08-8), with molecular formula C11H13Cl3N2O and molecular weight 294.01 g/mol. IUPAC: 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride.
Chemical Property Profile of Lofexidine Hydrochloride
Property Insights of Lofexidine Hydrochloride
The XLogP value of 3.18 indicates that Lofexidine Hydrochloride is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 33.6 Ų, Lofexidine Hydrochloride exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Lofexidine Hydrochloride has 2 hydrogen bond donor(s) and 2 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Lofexidine Hydrochloride?
The CAS number of Lofexidine Hydrochloride is 21498-08-8.
What is the molecular formula of Lofexidine Hydrochloride?
The molecular formula of Lofexidine Hydrochloride is C11H13Cl3N2O.
What is the molecular weight of Lofexidine Hydrochloride?
The molecular weight of Lofexidine Hydrochloride is 294.01 g/mol.
Where can I buy Lofexidine Hydrochloride?
You can request a quote for Lofexidine Hydrochloride directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Lofexidine Hydrochloride?
Yes, KEHONG BIO provides custom synthesis services for Lofexidine Hydrochloride and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.