4-Fluoro-2-hydroxyestradiol
TL;DR: 4-Fluoro-2-hydroxyestradiol (CAS 148044-30-8) is a chemical compound with molecular formula C18H23FO3 and molecular weight 306.16 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
(8R,9S,13S,14S,17S)-4-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,17-triol
Also Known As: 4-Fluoro-2-hydroxyestradiol, 4F2OHE2, 4-Fluoro-2-hydroxy-17beta-estradiol, 4-Fluoroestra-1(10),2,4-triene-2,3,17-triol, 4-Fluoroestra-1(10),2,4-triene-2,3,17beta-triol
| Molecular Formula | C18H23FO3 |
|---|---|
| Molecular Weight | 306.16 g/mol |
| LogP | 3.8 |
| Topological Polar Surface Area | 60.7 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 0 |
| Exact Mass | 306.16312 |
| Heavy Atoms | 22 |
| Complexity | 444.0 |
Chemical Identifiers
| CAS Number | 148044-30-8 |
|---|---|
| SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C(C(=C(C=C34)O)O)F |
| InChIKey | FMHAFUXKLBNHPP-ZICKVNAASA-N |
Product Overview
4-Fluoro-2-hydroxyestradiol (CAS 148044-30-8), with molecular formula C18H23FO3 and molecular weight 306.16 g/mol. IUPAC: (8R,9S,13S,14S,17S)-4-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,17-triol.
Chemical Property Profile of 4-Fluoro-2-hydroxyestradiol
Property Insights of 4-Fluoro-2-hydroxyestradiol
The XLogP value of 3.8 indicates that 4-Fluoro-2-hydroxyestradiol is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 60.7 Ų falls within the moderate polarity range, balancing permeability and solubility for 4-Fluoro-2-hydroxyestradiol. Following Lipinski's Rule of Five, 4-Fluoro-2-hydroxyestradiol has 3 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of 4-Fluoro-2-hydroxyestradiol?
The CAS number of 4-Fluoro-2-hydroxyestradiol is 148044-30-8.
What is the molecular formula of 4-Fluoro-2-hydroxyestradiol?
The molecular formula of 4-Fluoro-2-hydroxyestradiol is C18H23FO3.
What is the molecular weight of 4-Fluoro-2-hydroxyestradiol?
The molecular weight of 4-Fluoro-2-hydroxyestradiol is 306.16 g/mol.
Where can I buy 4-Fluoro-2-hydroxyestradiol?
You can request a quote for 4-Fluoro-2-hydroxyestradiol directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for 4-Fluoro-2-hydroxyestradiol?
Yes, KEHONG BIO provides custom synthesis services for 4-Fluoro-2-hydroxyestradiol and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.