Dolastatin 15
TL;DR: Dolastatin 15 (CAS 14543-43-2) is a chemical compound with molecular formula C45H68N6O9 and molecular weight 836.50 g/mol, supplied by Kehong Biological (Henan Kehong Biological Technology Co., Ltd.) with CRO/CDMO custom synthesis services.
[(2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2R)-2-[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-1-[(2S)-1-[(2S)-3-methyl-2-(methylamino)butanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate
Also Known As: Dolastatin 15, KST-1A1459, KST-1A1460, 2-DEOXYGUANOSINE-5-MONOPHOSPHATEAMMONIUMSALT, (2s)-1-[(2s)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1h-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl n-methyl-l-valyl-l-prolyl-2-{(2s)-2-[(n,n-dimethyl-l-valyl)amino]-3-methylbutanoyl}-l-prolinate
| Molecular Formula | C45H68N6O9 |
|---|---|
| Molecular Weight | 836.50 g/mol |
| LogP | 5.5 |
| Topological Polar Surface Area | 175.0 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 11 |
| Rotatable Bonds | 19 |
| Exact Mass | 836.50476 |
| Heavy Atoms | 60 |
| Complexity | 1620.0 |
Chemical Identifiers
| CAS Number | 14543-43-2 |
|---|---|
| SMILES | CC(C)[C@@H](C(=O)[C@]1(CCCN1C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC)C(=O)O[C@@H](C(C)C)C(=O)N3[C@H](C(=CC3=O)OC)CC4=CC=CC=C4)NC(=O)[C@H](C(C)C)N(C)C |
| InChIKey | KCXGUWDDPWDGHH-GZVUCVNVSA-N |
Product Overview
Dolastatin 15 (CAS 14543-43-2), with molecular formula C45H68N6O9 and molecular weight 836.50 g/mol. IUPAC: [(2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2R)-2-[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-1-[(2S)-1-[(2S)-3-methyl-2-(methylamino)butanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate.
Chemical Property Profile of Dolastatin 15
Property Insights of Dolastatin 15
The XLogP value of 5.5 indicates that Dolastatin 15 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 175.0 Ų indicates high polarity, suggesting Dolastatin 15 may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, Dolastatin 15 has 2 hydrogen bond donor(s) and 11 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
Frequently Asked Questions
What is the CAS number of Dolastatin 15?
The CAS number of Dolastatin 15 is 14543-43-2.
What is the molecular formula of Dolastatin 15?
The molecular formula of Dolastatin 15 is C45H68N6O9.
What is the molecular weight of Dolastatin 15?
The molecular weight of Dolastatin 15 is 836.50 g/mol.
Where can I buy Dolastatin 15?
You can request a quote for Dolastatin 15 directly from KEHONG BIO. Contact us or email info@kehongbio.com for pricing and availability.
Does KEHONG BIO offer custom synthesis for Dolastatin 15?
Yes, KEHONG BIO provides custom synthesis services for Dolastatin 15 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.